| Item Type | Name |
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Concept
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Dasatinib
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Concept
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Cognitive Aging
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Concept
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Neuroprotection
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Concept
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Superoxide Dismutase-1
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Concept
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Gastrointestinal Microbiome
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Concept
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Adipose Tissue
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Concept
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Animals
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Concept
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Aged
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Concept
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Aged, 80 and over
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Concept
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DNA (Cytosine-5-)-Methyltransferase 1
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Concept
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Antioxidants
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Concept
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Calcium
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Concept
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Alzheimer Disease
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Concept
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Blood-Brain Barrier
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Concept
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Body Composition
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Concept
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Body Weight
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Concept
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Behavior, Animal
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Concept
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Brain
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Concept
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Cause of Death
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Concept
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Cell Nucleus
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Concept
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Biology
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Concept
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Cachexia
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Concept
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Chronic Disease
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Concept
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Copper
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Concept
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Circadian Rhythm
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Concept
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Fibrosis
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Concept
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Carcinoma, Hepatocellular
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|
Concept
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Hippocampus
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Concept
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Humans
|
|
Concept
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Genetic Markers
|
|
Concept
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Hydrogen Peroxide
|
|
Concept
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Life Expectancy
|
|
Concept
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Lipid Peroxides
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|
Concept
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Lipopolysaccharides
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Concept
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Glucose Tolerance Test
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|
Concept
|
Liver Diseases
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|
Concept
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Liver Neoplasms
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Concept
|
Longevity
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Concept
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Glutathione Peroxidase
|
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Concept
|
Lactates
|
|
Concept
|
Magnetic Resonance Imaging
|
|
Concept
|
Inflammation
|
|
Concept
|
Neuromuscular Junction
|
|
Concept
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Neuronal Plasticity
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|
Concept
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Insulin
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|
Concept
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Insulin Resistance
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|
Concept
|
Multiple Sclerosis
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Concept
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Muscular Atrophy
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Concept
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Intestinal Mucosa
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|
Concept
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Necrosis
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Concept
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Obesity
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Concept
|
Mice, Inbred C57BL
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|
Concept
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Mice, Inbred Strains
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|
Concept
|
Microscopy, Fluorescence
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|
Concept
|
Middle Aged
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|
Concept
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Mitochondria
|
|
Concept
|
Motor Activity
|
|
Concept
|
Motor Neurons
|
|
Concept
|
Physical Endurance
|
|
Concept
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Paralysis
|
|
Concept
|
Sensitivity and Specificity
|
|
Concept
|
RNA, Messenger
|
|
Concept
|
Quality of Life
|
|
Concept
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Quercetin
|
|
Concept
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Signal Transduction
|
|
Concept
|
Biomarkers
|
|
Concept
|
Receptors, Cholinergic
|
|
Concept
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Zinc
|
|
Concept
|
Reproducibility of Results
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|
Concept
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Eicosanoids
|
|
Concept
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Lipid Peroxidation
|
|
Concept
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DNA Probes
|
|
Concept
|
Interleukin-10
|
|
Concept
|
Apoptosis
|
|
Concept
|
Sulfites
|
|
Concept
|
Neurofibrillary Tangles
|
|
Concept
|
Cell Death
|
|
Concept
|
Sequence Analysis, DNA
|
|
Concept
|
Vasodilator Agents
|
|
Concept
|
Carcinoma, Lewis Lung
|
|
Concept
|
Sample Size
|
|
Concept
|
Muscle, Skeletal
|
|
Concept
|
Muscle Fibers, Skeletal
|
|
Concept
|
Muscle Weakness
|
|
Concept
|
Weaning
|
|
Concept
|
DNA Methylation
|
|
Concept
|
Sirolimus
|
|
Concept
|
Oligonucleotide Array Sequence Analysis
|
|
Concept
|
F2-Isoprostanes
|
|
Concept
|
Mice, Knockout
|
|
Concept
|
Neurodegenerative Diseases
|
|
Concept
|
Caloric Restriction
|
|
Concept
|
Promoter Regions, Genetic
|
|
Concept
|
Calcium Signaling
|
|
Concept
|
Protein Processing, Post-Translational
|
|
Concept
|
5-Methylcytosine
|
|
Concept
|
NF-E2-Related Factor 2
|
|
Concept
|
Mitochondrial Membranes
|
|
Concept
|
Mice
|
|
Concept
|
Rats
|
|
Concept
|
Non-alcoholic Fatty Liver Disease
|
|
Concept
|
Neurogenesis
|
|
Concept
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Spatial Memory
|
|
Concept
|
Body Mass Index
|
|
Concept
|
Confidence Intervals
|
|
Concept
|
Odds Ratio
|
|
Concept
|
Transcriptome
|
|
Concept
|
Biomedical Research
|
|
Concept
|
Tumor Suppressor Protein p53
|
|
Concept
|
History, 20th Century
|
|
Concept
|
History, 21st Century
|
|
Concept
|
Receptor-Interacting Protein Serine-Threonine Kinases
|
|
Concept
|
Sarcoplasmic Reticulum Calcium-Transporting ATPases
|
|
Concept
|
Excitation Contraction Coupling
|
|
Concept
|
Core Binding Factor Alpha 2 Subunit
|
|
Concept
|
Retinal Dehydrogenase
|
|
Concept
|
Epigenomics
|
|
Concept
|
Phospholipases A2
|
|
Concept
|
Genomics
|
|
Concept
|
Models, Animal
|
|
Concept
|
Electron Transport Chain Complex Proteins
|
|
Concept
|
Kaplan-Meier Estimate
|
|
Concept
|
Young Adult
|
|
Concept
|
Sarcopenia
|
|
Concept
|
Peroxiredoxin III
|
|
Concept
|
Frailty
|
|
Concept
|
Autophagy
|
|
Concept
|
Cerebrovascular Circulation
|
|
Concept
|
Cholesterol
|
|
Concept
|
Disease Models, Animal
|
|
Concept
|
DNA
|
|
Concept
|
DNA Damage
|
|
Concept
|
Food
|
|
Concept
|
Gas Chromatography-Mass Spectrometry
|
|
Concept
|
Memory
|
|
Concept
|
Memory Disorders
|
|
Concept
|
Oklahoma
|
|
Academic Article
|
Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline.
|
|
Academic Article
|
Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia.
|
|
Academic Article
|
Role of DNA methylation in the dietary restriction mediated cellular memory.
|
|
Academic Article
|
Sexually divergent DNA methylation patterns with hippocampal aging.
|
|
Academic Article
|
Revisiting the genomic hypomethylation hypothesis of aging.
|
|
Academic Article
|
Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice.
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|
Academic Article
|
Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching.
|
|
Academic Article
|
Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia.
|
|
Academic Article
|
You Have Come A Long Way Baby: Five Decades of Research on the Biology of Aging From the Perspective of a Researcher Studying Aging.
|
|
Academic Article
|
Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice.
|
|
Academic Article
|
Cancer cachexia in a mouse model of oxidative stress.
|
|
Academic Article
|
The in vivo gene expression signature of oxidative stress.
|
|
Academic Article
|
How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story.
|
|
Academic Article
|
The Geropathology Grading Platform demonstrates that mice null for Cu/Zn-superoxide dismutase show accelerated biological aging.
|
|
Academic Article
|
The role of DNA methylation in epigenetics of aging.
|
|
Academic Article
|
Is Rapamycin a Dietary Restriction Mimetic?
|
|
Academic Article
|
Effect of rapamycin on aging and age-related diseases-past and future.
|
|
Academic Article
|
Reproducibility, sources of variability, pooling, and sample size: important considerations for the design of high-density oligonucleotide array experiments.
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|
Academic Article
|
Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice.
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|
Academic Article
|
Caloric restriction mitigates age-associated hippocampal differential CG and non-CG methylation.
|
|
Academic Article
|
Oxidative stress-induced dysregulation of excitation-contraction coupling contributes to muscle weakness.
|
|
Academic Article
|
The role of macromolecular damage in aging and age-related disease.
|
|
Academic Article
|
Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype.
|
|
Academic Article
|
Significant life extension by ten percent dietary restriction.
|
|
Academic Article
|
Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation.
|
|
Academic Article
|
A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse.
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|
Academic Article
|
Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice.
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|
Academic Article
|
Necroptosis increases with age and is reduced by dietary restriction.
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|
Academic Article
|
Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice.
|
|
Academic Article
|
Targeting cPLA2 derived lipid hydroperoxides as a potential intervention for sarcopenia.
|
|
Grant
|
BLR&D Research Career Scientist Award Application
|
|
Grant
|
Can Rapamycin Retard Age-Related Diseases?
|
|
Grant
|
TESTING THE ABILITY OF NOVEL ASSAYS OF RESILIENCE TO PREDICT LIFESPAN
|
|
Grant
|
Does overexpressing Cu/Zn superoxide dismutase retard aging in rodents
|
|
Grant
|
Summer Training Course in Aging Research
|
|
Grant
|
Multiplex Protein Quantification Core
|
|
Grant
|
TRANSGENIC MODELS TESTING ROLE OF DNA DAMAGE IN AGING
|
|
Grant
|
Does Dietary Restriction Alter Stem Cell Function Through An Epigenetic Mechanism?
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|
Grant
|
Interaction of Genotype and Level of Dietary Restriction on Lifespan and Aging
|
|
Grant
|
NUTRITIONAL PROBE OF THE AGING PROCESS
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|
Grant
|
1991 GORDON RESEARCH CONFERENCE ON THE BIOLOGY OF AGING
|
|
Grant
|
Protein Oxidation as a Factor in the Mechanism of Aging
|
|
Grant
|
Does Necroptosis Play a Role in Inflammation and Aging
|
|
Grant
|
TRANSGENIC MICE, AGING, CANCER, AND OXIDATIVE DAMAGE
|
|
Grant
|
EFFECT OF DIETARY RESTRICTION ON GENE EXPRESSION
|
|
Academic Article
|
Calorie restriction prevents age-related changes in the intestinal microbiota.
|
|
Academic Article
|
Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model.
|
|
Academic Article
|
Necroptosis contributes to chronic inflammation and fibrosis in aging liver.
|
|
Academic Article
|
Muscle mitochondrial catalase expression prevents neuromuscular junction disruption, atrophy, and weakness in a mouse model of accelerated sarcopenia.
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|
Academic Article
|
Litter expansion alters metabolic homeostasis in a sex specific manner.
|
|
Academic Article
|
Oklahoma Nathan Shock Aging Center - assessing the basic biology of aging from genetics to protein and function.
|
|
Academic Article
|
Reevaluation of the effect of dietary restriction on different recombinant inbred lines of male and female mice.
|
|
Academic Article
|
Necroptosis increases with age in the brain and contributes to age-related neuroinflammation.
|
|
Academic Article
|
A Genetically Heterogeneous Rat Model with Divergent Mitochondrial Genomes.
|
|
Academic Article
|
Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis.
|
|
Academic Article
|
Senolytic treatment does not mitigate oxidative stress-induced muscle atrophy but improves muscle force generation in CuZn superoxide dismutase knockout mice.
|
|
Academic Article
|
MLKL overexpression leads to Ca2+ and metabolic dyshomeostasis in a neuronal cell model.
|